Model validation for a noninvasive arterial stenosis detection problem

Copyright @ 2013 American Institute of Mathematical SciencesA current thrust in medical research is the development of a non-invasive method for detection, localization, and characterization of an arterial stenosis (a blockage or partial blockage in an artery). A method has been proposed to detect shear waves in the chest cavity which have been generated by disturbances in the blood flow resulting from a stenosis. In order to develop this methodology further, we use both one-dimensional pressure and shear wave experimental data from novel acoustic phantoms to validate corresponding viscoelastic mathematical models, which were developed in a concept paper [8] and refined herein. We estimate model parameters which give a good fit (in a sense to be precisely defined) to the experimental data, and use asymptotic error theory to provide confidence intervals for parameter estimates. Finally, since a robust error model is necessary for accurate parameter estimates and confidence analysis, we include a comparison of absolute and relative models for measurement error.The National Institute of Allergy and Infectious Diseases, the Air Force Office of Scientific Research, the Deopartment of Education and the Engineering and Physical Sciences Research Council (EPSRC)

Magnetic-Moment Fragmentation and Monopole Crystallization

The Coulomb phase, with its dipolar correlations and pinch-point-scattering patterns, is central to discussions of geometrically frustrated systems, from water ice to binary and mixed-valence alloys, as well as numerous examples of frustrated magnets. The emergent Coulomb phase of lattice-based systems has been associated with divergence-free fields and the absence of long-range order. Here, we go beyond this paradigm, demonstrating that a Coulomb phase can emerge naturally as a persistent fluctuating background in an otherwise ordered system. To explain this behavior, we introduce the concept of the fragmentation of the field of magnetic moments into two parts, one giving rise to a magnetic monopole crystal, the other a magnetic fluid with all the characteristics of an emergent Coulomb phase. Our theory is backed up by numerical simulations, and we discuss its importance with regard to the interpretation of a number of experimental results

A model for predicting dissolved organic carbon distribution in a reservoir water using fluorescence spectroscopy

A number of water treatment works (WTW) in the north of England (UK) have experienced problems in reducing the dissolved organic carbon (DOC) present in the water to a sufficiently low level. The problems are experienced in autumn/ winter when the colour increases and the coagulant dose at the WTW needs to be increased in order to achieve sufficient colour removal. However, the DOC content of the water varies little throughout the year. To investigate this further, the water was fractionated using resin adsorption techniques into its hydrophobic (fulvic and humic acid fractions) and hydrophilic (acid and non-acid fractions) components. The fractionation process yields useful information on the changing concentration of each fraction but is time consuming and labour intensive. Here, a method of rapidly determining fraction concentration was developed using fluorescence spectroscopy. The model created used synchronous spectra of fractionated material compared against bulk water spectra and predicted the fraction concentrations to within 10% for a specific water. The model was unable to predict fraction concentrations for waters from a different watershed

Reduced dimensionality spin-orbit dynamics of CH3 + HCl reversible arrow CH4 Cl on ab initio surfaces

A reduced dimensionality quantum scattering method is extended to the study of spin-orbit nonadiabatic transitions in the CH3 + HCl reversible arrow CH4 + Cl(P-2(J)) reaction. Three two-dimensional potential energy surfaces are developed by fitting a 29 parameter double-Morse function to CCSD(T)/IB//MP2/cc-pV(T+d)Z-dk ab initio data; interaction between surfaces is described by geometry-dependent spin-orbit coupling functions fit to MCSCF/cc-pV(T+d)Z-dk ab initio data. Spectator modes are treated adiabatically via inclusion of curvilinear projected frequencies. The total scattering wave function is expanded in a vibronic basis set and close-coupled equations are solved via R-matrix propagation. Ground state thermal rate constants for forward and reverse reactions agree well with experiment. Multi-surface reaction probabilities, integral cross sections, and initial-state selected branching ratios all highlight the importance of vibrational energy in mediating nonadiabatic transition. Electronically excited state dynamics are seen to play a small but significant role as consistent with experimental conclusions. (C) 2011 American Institute of Physics. [doi:10.1063/1.3592732

A Matrix Big Bang

The light-like linear dilaton background represents a particularly simple time-dependent 1/2 BPS solution of critical type IIA superstring theory in ten dimensions. Its lift to M-theory, as well as its Einstein frame metric, are singular in the sense that the geometry is geodesically incomplete and the Riemann tensor diverges along a light-like subspace of codimension one. We study this background as a model for a big bang type singularity in string theory/M-theory. We construct the dual Matrix theory description in terms of a (1+1)-d supersymmetric Yang-Mills theory on a time-dependent world-sheet given by the Milne orbifold of (1+1)-d Minkowski space. Our model provides a framework in which the physics of the singularity appears to be under control.Comment: 25 pages, LaTeX; v2: discussion of singularity of Einstein frame metric added, references adde

Lattice Supersymmetry and Topological Field Theory

It is known that certain theories with extended supersymmetry can be discretized in such a way as to preserve an exact fermionic symmetry. In the simplest model of this kind, we show that this residual supersymmetric invariance is actually a BRST symmetry associated with gauge fixing an underlying local shift symmetry. Furthermore, the starting lattice action is then seen to be entirely a gauge fixing term. The corresponding continuum theory is known to be a topological field theory. We look, in detail, at one example - supersymmetric quantum mechanics which possesses two such BRST symmetries. In this case, we show that the lattice theory can be obtained by blocking out of the continuum in a carefully chosen background metric. Such a procedure will not change the Ward identities corresponding to the BRST symmetries since they correspond to topological observables. Thus, at the quantum level, the continuum BRST symmetry is preserved in the lattice theory. Similar conclusions are reached for the two-dimensional complex Wess-Zumino model and imply that all the supersymmetric Ward identities are satisfied {\it exactly} on the lattice. Numerical results supporting these conclusions are presented.Comment: 18 pages, 2 figure

Exact Lattice Supersymmetry: the Two-Dimensional N=2 Wess-Zumino Model

We study the two-dimensional Wess-Zumino model with extended N=2 supersymmetry on the lattice. The lattice prescription we choose has the merit of preserving {\it exactly} a single supersymmetric invariance at finite lattice spacing $a$. Furthermore, we construct three other transformations of the lattice fields under which the variation of the lattice action vanishes to $O(ga^2)$ where $g$ is a typical interaction coupling. These four transformations correspond to the two Majorana supercharges of the continuum theory. We also derive lattice Ward identities corresponding to these exact and approximate symmetries. We use dynamical fermion simulations to check the equality of the massgaps in the boson and fermion sectors and to check the lattice Ward identities. At least for weak coupling we see no problems associated with a lack of reflection positivity in the lattice action and find good agreement with theory. At strong coupling we provide evidence that problems associated with a lack of reflection positivity are evaded for small enough lattice spacing.Comment: 29 pages, 10 figures. New results at strong coupling added. Minor corrections to text and one reference added. Version to appear in Phys. Rev.

Quantum field theory on manifolds with a boundary

We discuss quantum theory of fields \phi defined on (d+1)-dimensional manifold {\cal M} with a boundary {\cal B}. The free action W_{0}(\phi) which is a bilinear form in \phi defines the Gaussian measure with a covariance (Green function) {\cal G}. We discuss a relation between the quantum field theory with a fixed boundary condition \Phi and the theory defined by the Green function {\cal G}. It is shown that the latter results by an average over \Phi of the first. The QFT in (anti)de Sitter space is treated as an example. It is shown that quantum fields on the boundary are more regular than the ones on (anti) de Sitter space.Comment: The version to appear in Journal of Physics A, a discussion on the relation to other works in the field is adde

Thermal phases of D1-branes on a circle from lattice super Yang-Mills

We report on the results of numerical simulations of 1+1 dimensional SU(N) Yang-Mills theory with maximal supersymmetry at finite temperature and compactified on a circle. For large N this system is thought to provide a dual description of the decoupling limit of N coincident D1-branes on a circle. It has been proposed that at large N there is a phase transition at strong coupling related to the Gregory-Laflamme (GL) phase transition in the holographic gravity dual. In a high temperature limit there was argued to be a deconfinement transition associated to the spatial Polyakov loop, and it has been proposed that this is the continuation of the strong coupling GL transition. Investigating the theory on the lattice for SU(3) and SU(4) and studying the time and space Polyakov loops we find evidence supporting this. In particular at strong coupling we see the transition has the parametric dependence on coupling predicted by gravity. We estimate the GL phase transition temperature from the lattice data which, interestingly, is not yet known directly in the gravity dual. Fine tuning in the lattice theory is avoided by the use of a lattice action with exact supersymmetry.Comment: 21 pages, 8 figures. v2: References added, two figures were modified for clarity. v3: Normalisation of lattice coupling corrected by factor of two resulting in change of estimate for c_cri

Holographic Walking Technicolor and Stability of Techni-Branes

Techni-fermions are added as stacks of D7-anti-D7 techni-branes within the framework of a holographic technicolor model that has been proposed as a realization of walking technicolor. The stability of the embedding of these branes is determined. When a sufficiently low bulk cut-off is provided the fluctuations remain small. For a longer walking region, as would be required in any realistic model of electroweak symmetry breaking, a larger bulk cut-off is needed and in this case the oscillations destabilize.Comment: Latex, 25 pages, 10 figure